BDBM8163 N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{6-methylpyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 54

SMILES Cc1ccc2c(cnn2n1)-c1ccnc(Nc2ccc3OCCOc3c2)n1

InChI Key InChIKey=NKTGKAVJSAUPCX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8163   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8163(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{6-methylpy...)
Affinity DataIC50: 6nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

LigandPNGBDBM8163(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{6-methylpy...)
Affinity DataIC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
LigandPNGBDBM8163(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{6-methylpy...)
Affinity DataIC50: 79nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed