BDBM81774 CAS_15676-16-1::SULPIRIDE,(+)::Sulpiride-S::Sulpiride-l
SMILES CCN1CCC[C@H]1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
InChI Key InChIKey=BGRJTUBHPOOWDU-NSHDSACASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 53 hits for monomerid = 81774
Affinity DataKi: 6.90nMAssay Description:Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatumMore data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Binding affinity towards dopamine receptor D2 using as [3H]-spiperone radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Inhibitory concentration required for displacing radioligand [3H]SPI from DA D-2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in ratMore data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D2L stably expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Binding affinity towards human Dopamine receptor D2 (short) by [3H]-spiperone displacement.More data for this Ligand-Target Pair
Affinity DataKi: 88nMAssay Description:In vitro displacement of [3H]spiperone from the cloned human dopamine receptor D3 stably expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 88nMAssay Description:Binding affinity towards human dopamine D3 receptor by [3H]spiperone displacement.More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D2L stably expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Binding affinity towards human Dopamine receptor D2 (long) by [3H]-spiperone displacement.More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortexMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampusMore data for this Ligand-Target Pair
TargetSerotonin 2 (5-HT2) receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A/1B/1D/1F(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortexMore data for this Ligand-Target Pair
Affinity DataKi: 2.10E+3nMAssay Description:In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D4 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.10E+3nMAssay Description:Binding affinity towards human Dopamine receptor D4 by [3H]spiperone displacement.More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 1.50E+4nMAssay Description:Ability to inhibit [3H]WB-4101 binding to alpha-1 adrenergic receptor was determined in ratMore data for this Ligand-Target Pair
TargetSerotonin 2 (5-HT2) receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 2.70E+4nMAssay Description:Ability to inhibit [3H]spiperone binding to 5-hydroxytryptamine 2 receptor determined in ratMore data for this Ligand-Target Pair
Affinity DataKi: 5.00E+4nMAssay Description:Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.More data for this Ligand-Target Pair
Affinity DataKi: 5.00E+4nMAssay Description:In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 233nMAssay Description:Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPIMore data for this Ligand-Target Pair
Affinity DataIC50: 7.68E+3nMAssay Description:Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed b...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair