BDBM83319 1-[2-(dimethylamino)-2-(3-pyridinyl)ethyl]-3-(3-methylphenyl)thiourea::1-[2-(dimethylamino)-2-(3-pyridyl)ethyl]-3-(m-tolyl)thiourea::1-[2-(dimethylamino)-2-pyridin-3-yl-ethyl]-3-(3-methylphenyl)thiourea::1-[2-(dimethylamino)-2-pyridin-3-ylethyl]-3-(3-methylphenyl)thiourea::MLS000720335::SMR000236204::cid_3600177

SMILES Cc1c(O)cc(F)c(C)c1n3c(N)c(C(N)=O)c2cc(Cl)cnc23

InChI Key InChIKey=FAEPGMOWWWEYCC-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 83319   

TargetTyrosine-protein kinase Lck(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 83319BDBM83319(2-amino-5-chloro-1-(3-fluoro-5-hydroxy-2,6-dimethy...)
Affinity DataIC50: 50nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 83319BDBM83319(2-amino-5-chloro-1-(3-fluoro-5-hydroxy-2,6-dimethy...)
Affinity DataIC50: 50nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent