BDBM8573 4-Acylamino-6-arylfuro[2,3-d]pyrimidine 18::N-[6-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yl]cyclopropanecarboxamide

SMILES Fc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1

InChI Key InChIKey=LZMLKLSKVZPPFJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8573   

TargetGlycogen synthase kinase-3 beta(Human)
Tsukuba Research Laboratories

LigandPNGBDBM8573(N-[6-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yl]cyc...)
Affinity DataIC50: 575nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2006
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tsukuba Research Laboratories

LigandPNGBDBM8573(N-[6-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yl]cyc...)
Affinity DataIC50: 2.04E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Tsukuba Research Laboratories

LigandPNGBDBM8573(N-[6-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yl]cyc...)
Affinity DataIC50: 1.90E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2006
Entry Details Article
PubMed