BDBM8575 4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20::N-{6-phenylfuro[2,3-d]pyrimidin-4-yl}cyclopentanecarboxamide

SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CCCC1

InChI Key InChIKey=NJTNOAYYSGUBCP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8575   

TargetGlycogen synthase kinase-3 beta(Human)
Tsukuba Research Laboratories

LigandPNGBDBM8575(N-{6-phenylfuro[2,3-d]pyrimidin-4-yl}cyclopentanec...)
Affinity DataIC50: 23nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Tsukuba Research Laboratories

LigandPNGBDBM8575(N-{6-phenylfuro[2,3-d]pyrimidin-4-yl}cyclopentanec...)
Affinity DataIC50: 23nMAssay Description:Inhibition of Glycogen synthase kinase-3 beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Tsukuba Research Laboratories

LigandPNGBDBM8575(N-{6-phenylfuro[2,3-d]pyrimidin-4-yl}cyclopentanec...)
Affinity DataIC50: 1.90E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2006
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tsukuba Research Laboratories

LigandPNGBDBM8575(N-{6-phenylfuro[2,3-d]pyrimidin-4-yl}cyclopentanec...)
Affinity DataIC50: 2.30E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2006
Entry Details Article
PubMed