BDBM86615 Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 21
SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3N(C)C(=O)c4ccccc4N(C)c3n2)cc1C
InChI Key InChIKey=PHENCDSAYZNXRO-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 86615
Affinity DataIC50: 3.70nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)
Curated by ChEMBL
University of Science and Technology (Ust)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
Affinity DataIC50: 14.5nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair