BDBM86620 Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 26

SMILES CCN1CCN(Cc2ccc(Nc3ncc4N(C)C(=O)c5ccccc5Oc4n3)cc2C(F)(F)F)CC1

InChI Key InChIKey=HTOAYVQONNPMFN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 86620   

TargetAurora kinase A(Human)
Harvard Medical School

LigandChemical structure of BindingDB Monomer ID 86620BDBM86620(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50: 457nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

LigandChemical structure of BindingDB Monomer ID 86620BDBM86620(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50: 3.04E+3nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2012
Entry Details Article
PubMed