BDBM87131 4-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylidene-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid::4-fluoro-N-[2-[1-(3-fluorophenyl)-4-keto-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide;2,2,2-trifluoroacetic acid::4-fluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide;2,2,2-trifluoroacetic acid::CHEMBL1254654::VU0418637-1::cid_46939874

SMILES Fc1ccc(cc1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1

InChI Key InChIKey=AUTVGUGBVJTDOF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 87131   

TargetPhospholipase D2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM87131(cid_46939874 | 4-fluoro-N-[2-[1-(3-fluorophenyl)-4...)
Affinity DataIC50: 350nMAssay Description:Inhibition of GFP-tagged PLD2 in human HEK293 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhospholipase D2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM87131(cid_46939874 | 4-fluoro-N-[2-[1-(3-fluorophenyl)-4...)
Affinity DataIC50: 6.69E+3nMAssay Description:Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2012
Entry Details
PCBioAssay
TargetPhospholipase D2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM87131(cid_46939874 | 4-fluoro-N-[2-[1-(3-fluorophenyl)-4...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human GST-tagged PLD2A in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM87131(cid_46939874 | 4-fluoro-N-[2-[1-(3-fluorophenyl)-4...)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of PLD1 in human Calu-1 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM87131(cid_46939874 | 4-fluoro-N-[2-[1-(3-fluorophenyl)-4...)
Affinity DataIC50: 1.20E+4nMAssay Description:Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2012
Entry Details
PCBioAssay
TargetPhospholipase D1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM87131(cid_46939874 | 4-fluoro-N-[2-[1-(3-fluorophenyl)-4...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of PLD1 in human calu1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed