BDBM92796 Bisanilinopyrimidine, 3j::US9249124, YL5-080

SMILES Cc1cnc(Nc2ccc(cc2)C(O)=O)nc1Nc1ccccc1C(O)=O

InChI Key InChIKey=RZKXJGQEKOAZKA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 92796   

TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 92796BDBM92796(Bisanilinopyrimidine, 3j | US9249124, YL5-080)
Affinity DataIC50: 145nMAssay Description:The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting ox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 92796BDBM92796(Bisanilinopyrimidine, 3j | US9249124, YL5-080)
Affinity DataIC50: 281nMpH: 7.4 T: 2°CAssay Description:Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 92796BDBM92796(Bisanilinopyrimidine, 3j | US9249124, YL5-080)
Affinity DataIC50: 281nMAssay Description:In vitro enzyme activity assay using Aurora Kinase A. More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2013
Entry Details Article
PubMed