BDBM92828 Bisanilinopyrimidine, 9a::US9249124, 45

SMILES Clc1ccccc1Nc1ccnc(Nc2ccc(cc2)C(=O)NCCN2CCOCC2)n1

InChI Key InChIKey=DKDRRZIRAAABEN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 92828   

TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 92828BDBM92828(Bisanilinopyrimidine, 9a | US9249124, 45)
Affinity DataIC50: 28.1nMpH: 7.4 T: 2°CAssay Description:Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
US Patent

TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 92828BDBM92828(Bisanilinopyrimidine, 9a | US9249124, 45)
Affinity DataIC50: 216nMAssay Description:In vitro enzyme activity assay using Aurora Kinase A. More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Moffitt Cancer Center

LigandChemical structure of BindingDB Monomer ID 92828BDBM92828(Bisanilinopyrimidine, 9a | US9249124, 45)
Affinity DataIC50: 232nMAssay Description:In vitro enzyme activity assay using Aurora Kinase A. More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 92828BDBM92828(Bisanilinopyrimidine, 9a | US9249124, 45)
Affinity DataIC50: 5.50E+3nMT: 2°CAssay Description:Specifically, MDA-MB-468 cells (American Type Culture Collection) were maintained in Dulbecco's modified Eagle's medium (DMEM) plus 10% fetus bovine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
US Patent