BDBM97498 Roche-Dataset for PDE10A, Compound 284::US8470820, 9

SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccc1

InChI Key InChIKey=GPSZQLBOJJYDJA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 97498   

LigandPNGBDBM97498(US8470820, 9 | Roche-Dataset for PDE10A, Compound ...)
Affinity DataIC50: 121nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed
LigandPNGBDBM97498(US8470820, 9 | Roche-Dataset for PDE10A, Compound ...)
Affinity DataIC50: 122nMpH: 7.5Assay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 ul contained 20 mM HEPES pH=7.5/10 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2013
Entry Details
US Patent