BDBM97499 Roche-Dataset for PDE10A, Compound 103::US8470820, 10

SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1

InChI Key InChIKey=PNQGMRYTSZRWLB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 97499   

LigandPNGBDBM97499(US8470820, 10 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 ul contained 20 mM HEPES pH=7.5/10 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2013
Entry Details
US Patent

LigandPNGBDBM97499(US8470820, 10 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 2.25nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed