BDBM97508 Roche-Dataset for PDE10A, Compound 295::US8470820, 19

SMILES CCc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1

InChI Key InChIKey=KNWPZZGSEGMAGU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 97508   

LigandPNGBDBM97508(US8470820, 19 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 1.98nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed
LigandPNGBDBM97508(US8470820, 19 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 ul contained 20 mM HEPES pH=7.5/10 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2013
Entry Details
US Patent