BDBM97548 Roche-Dataset for PDE10A, Compound 472::US8470820, 59

SMILES COCc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1

InChI Key InChIKey=NYKBBNJZKRWKSJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 97548   

LigandPNGBDBM97548(US8470820, 59 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 6.57nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed
LigandPNGBDBM97548(US8470820, 59 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 7nMpH: 7.5Assay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 ul contained 20 mM HEPES pH=7.5/10 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2013
Entry Details
US Patent