BDBM97553 Roche-Dataset for PDE10A, Compound 1097::US8470820, 65

SMILES O=C(Nc1cnn(c1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1

InChI Key InChIKey=MHKSLGAXBAGRDE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 97553   

LigandPNGBDBM97553(US8470820, 65 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 55nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed
LigandPNGBDBM97553(US8470820, 65 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 55nMpH: 7.5Assay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 ul contained 20 mM HEPES pH=7.5/10 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2013
Entry Details
US Patent