BDBM97559 US10189794, Compound I-145::US10618902, Compound I-145::US9695132, I-145

SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)-c4nnn(C)n4)nc3N(C)C2=O)c1Cl

InChI Key InChIKey=IGNJKJKHQQECPI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 97559   

TargetFibroblast growth factor receptor 4(Human)
Celgene Car

US Patent
LigandPNGBDBM97559(US9695132, I-145 | US10189794, Compound I-145 | US...)
Affinity DataIC50: 100nMAssay Description:A 10× stock solution of FGFR4-WT (PR4380C), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 7, was prepared as described below...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Celgene Car

US Patent
LigandPNGBDBM97559(US9695132, I-145 | US10189794, Compound I-145 | US...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Celgene Car

US Patent
LigandPNGBDBM97559(US9695132, I-145 | US10189794, Compound I-145 | US...)
Affinity DataIC50: 500nMAssay Description:A 10× stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent