BDBM99583 US8501936, 82

SMILES CN1CCN(CC1)c1ccc(Nc2nc3cccc(-c4cccc(c4)S(C)(=O)=O)n3n2)cc1

InChI Key InChIKey=XEFMGFQXNLZBQW-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 99583   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM99583(US8501936, 82)
Affinity DataKi:  2nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM99583(US8501936, 82)
Affinity DataIC50: 9.20nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2013
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM99583(US8501936, 82)
Affinity DataIC50: 73nMAssay Description:Inhibition of JAK2 in human SET2 cells assessed as reduction of phosphorylated STAT5 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cephalon

US Patent
LigandPNGBDBM99583(US8501936, 82)
Affinity DataIC50: 138nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2013
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Cephalon

US Patent
LigandPNGBDBM99583(US8501936, 82)
Affinity DataIC50: 584nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2013
Entry Details
US Patent