BDBM50353371 BMS-345541::CHEMBL471496

SMILES Cc3ccc2nc(NCCN)c1ncc(C)n1c2c3

InChI Key InChIKey=PSPFQEBFYXJZEV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50353371   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353371BDBM50353371(BMS-345541 | CHEMBL471496)
Affinity DataIC50: 2.76E+3nMAssay Description:Inhibition of IKK in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353371BDBM50353371(BMS-345541 | CHEMBL471496)
Affinity DataIC50: 3.09E+3nMAssay Description:Inhibition of IKK in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353371BDBM50353371(BMS-345541 | CHEMBL471496)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of IKK in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353371BDBM50353371(BMS-345541 | CHEMBL471496)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of IKK in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353371BDBM50353371(BMS-345541 | CHEMBL471496)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of GST-tagged IKK1 (unknown origin) expressed in High five cells using LDDRHDSGLDSMKDEEY as substrate incubated for 5 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353371BDBM50353371(BMS-345541 | CHEMBL471496)
Affinity DataIC50: 4.27E+3nMAssay Description:Inhibition of IKK in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353371BDBM50353371(BMS-345541 | CHEMBL471496)
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of IKK in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed