BDBM50611355 CLN-081::CLN081::Cln 081::Cln-081::TAS-6417::TAS6417::TPC-064::TPC064::Zipalertinib

SMILES CC1=C[C@@H](Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc21)NC(=O)C=C

InChI Key InChIKey=MKCYPWYURWOKST-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50611355   

TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 3nMAssay Description:Inhibition of 6His-tagged TEV-GS fused EGFR D770_N771insNPG mutant (G696 to G1210 reisudes) (unknown origin) expressed in Sf21 cells using Poly(Glu,T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant wildtype human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in Sf21 insect cells using Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of EGFR-D770-N771insNPG mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 8nMAssay Description:Inhibition of wildtype EGFR (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 21nMAssay Description:Inhibition of EGFR D770_N771insSVD mutant (unknown origin) phosphorylation transfected in human NCI-H2073 cells incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 57nMAssay Description:Inhibition of EGFR D770_N771insSVD mutant (unknown origin) phosphorylation transfected in human NCI-H2073 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 77nMAssay Description:Inhibition of wildtype EGFR (unknown origin) phosphorylation transfected in human NCI-H2073 cells preincubated for 2 hrs followed by EGF stimulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 190nMAssay Description:Inhibition of wildtype EGFR (unknown origin) phosphorylation transfected in human NCI-H2073 cells preincubated for 2 hrs followed by EGF stimulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed