BDBM50277173 CHEBI:3329::Calotropin

SMILES [H][C@@]12C[C@]3([H])CC[C@]4([H])[C@]([H])(CC[C@]5(C)[C@H](CC[C@]45O)C4=CC(=O)OC4)[C@]3(C[C@@]1([H])O[C@@]1(O)[C@@H](O)C[C@@H](C)O[C@@]1([H])O2)C=O

InChI Key InChIKey=OWPWFVVPBYFKBG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50277173   

TargetNeurogenic locus notch homolog protein 1(Human)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50277173(CHEBI:3329 | Calotropin)
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant mouse N-terminal FLAG-tagged Notch1 (1704 to 2531 residues) expressed in human LS174T cells assessed as reduction in doxycy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2020
Entry Details Article
PubMed