BDBM18376 (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid::Cerivastatin::cid_446156
SMILES COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)c1-c1ccc(F)cc1)C(C)C
InChI Key InChIKey=SEERZIQQUAZTOL-ANMDKAQQSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 18376
Affinity DataIC50: 9.80nM EC50: 2.30nMpH: 7.0 T: 37°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductaseMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Human)
Southern Research Institute
Curated by PubChem BioAssay
Southern Research Institute
Curated by PubChem BioAssay
Affinity DataIC50: 2.80nMpH: 7.2 T: 37°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nM EC50: 1.70nMpH: 7.2 T: 37°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair