BDBM50095952 CHEMBL3593777
SMILES NC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(C[C@@H]1F)c1ccc(cn1)C#N
InChI Key InChIKey=QZIQXTJSJONATN-ZCUDWAKFSA-N
Data 40 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 40 hits for monomerid = 50095952
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells incubated for 10 mins by Rb efflux assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human JAK1 assessed as reduction in phosphorylation of Biotin-Lyn-Substrate-2 after 1 hr in presence of ATP by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EPHA2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of CDK2/CycA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 980nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Astellas Pharma
Curated by ChEMBL
Astellas Pharma
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CaMK2a (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of PKCtheta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of p70S6K (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of AurC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MEKK1 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Astellas Pharma
Curated by ChEMBL
Astellas Pharma
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of BMPR1A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of TIE2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human JAK2 assessed as reduction in phosphorylation of Biotin-Lyn-Substrate-2 after 1 hr in presence of ATP by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells after 10 mins by Rb efflux assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human JAK3 assessed as reduction in phosphorylation of Biotin-Lyn-Substrate-2 after 1 hr in presence of ATP by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA methodMore data for this Ligand-Target Pair