BDBM50140905 19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),5,7,12,14,16(22)-hexaen-13-ol

SMILES CN1CC[C@@]23[C@H]4Oc5c2c(CC1[C@@H]3Cc1cc(cnc41)-c1ccccc1)ccc5O

InChI Key InChIKey=GRNLHIJZMLLROK-FMMCSPAXSA-N

Data  6 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50140905   

TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataKi:  24nMAssay Description:Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataKi:  81nMAssay Description:Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataKi: >1.00E+3nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor kappa 1 in [35S]GTP-gamma-S, binding assay in guinea pig c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataKi: >1.00E+3nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataKi: >1.00E+3nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor mu 1 in [35S]GTP-gamma-S, binding assay in guinea pig caud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataIC50:  48nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataIC50:  99nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataEC50:  1.03E+3nMAssay Description:Antagonism of compound towards Opioid receptor mu 1 was determined using PL-017 in guinea pig ileum (GPI) smooth muscle contraction assays; d = agoni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed