BDBM50140913 6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),5,7,12,14,16(22)-hexaen-13-ol

SMILES Oc1ccc2CC3[C@@H]4Cc5cc(cnc5[C@@H]5Oc1c2[C@]45CCN3CC1CC1)-c1ccc(Cl)cc1

InChI Key InChIKey=GSOFQIRSCHLMHR-OPECHTPQSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50140913   

TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataKi:  1.60nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataKi:  6nMAssay Description:Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataKi:  9.20nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor mu 1 in [35S]GTP-gamma-S, binding assay in guinea pig caud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataKi:  11nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards kappa opioid receptors in [35S]GTP-gamma-S, binding assay in guinea pig ca...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataKi:  62nMAssay Description:Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataIC50:  109nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed