BDBM50287520 CHEMBL4159883
SMILES COc1ccc(cc1S(=O)(=O)Nc1ccc(Cl)cc1)C(=O)NC(C)c1cnn(C)n1
InChI Key InChIKey=DERVNKULTWJINM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50287520
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 2.80E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 391nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells at -75 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 398nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 158nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair