BDBM50634776 Donepezil::Donepezilo::D-797::Donaz
SMILES COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 66 hits for monomerid = 50634776
Affinity DataIC50: 0.0490nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodide as substrate incubated for 15 to 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human SGLT2 assessed as inhibition of methyl-alpha-D-glucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of PDE5A1 (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured after 10 mi...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and m...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 30 min by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pre-incubated for 30 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of electric eel AChE assessed as residual enzyme activity using acetylthiocholine iodide as substrate and measured for 10 mins by Ellman's...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with compounds for 20 mins followed by substrate addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition by DTNB base...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured after 15 to 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 227nMAssay Description:Inhibition of human BACE-1 measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 941nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of human BACE-1 using (7-Methoxycoumarin-4-acetyl-[Asn670, Leu671]-Amyloid beta/A4 precursor protein 770 fragments 667-676- (2, 4-dinitrop...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of horse serum BChE assessed as residual enzyme activity using butyrylthiocholine iodide as substrate by Ellman's colorimetric assayMore data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 2.58E+3nMAssay Description:Inhibition of human BuChE measured after 15 to 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 3.21E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair