BDBM50634776 D-797::Donaz::Donepezil::Donepezilo
SMILES COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2
InChI Key InChIKey=ADEBPBSSDYVVLD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 66 hits for monomerid = 50634776
Affinity DataIC50: 0.0490nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodide as substrate incubated for 15 to 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human SGLT2 assessed as inhibition of methyl-alpha-D-glucopyranoside uptake by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
Affinity DataIC50: 9.90nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of PDE5A1 (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate incubated for 5 minsMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity to S1R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured after 10 mi...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and m...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 30 min by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pre-incubated for 30 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of electric eel AChE assessed as residual enzyme activity using acetylthiocholine iodide as substrate and measured for 10 mins by Ellman's...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with compounds for 20 mins followed by substrate addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant AChE (unknown origin) preincubated for 30 mins followed by substrate addition by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human AChE using ATCI as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition by DTNB base...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate pre-incubated for 10 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of human erythrocytes AChE measured after 10 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of BACE-1 (unknown origin) 667-676- (2, 4-dinitrophenyl) Lys-Arg-Arg amide trifluoroacetate as substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured after 15 to 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 227nMAssay Description:Inhibition of human BACE-1 measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of AChE (unknown origin) incubated for 40 mins in presence of substrateMore data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 941nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of human BACE-1 using (7-Methoxycoumarin-4-acetyl-[Asn670, Leu671]-Amyloid beta/A4 precursor protein 770 fragments 667-676- (2, 4-dinitrop...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of AChE (unknown origin) by Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of horse serum BChE assessed as residual enzyme activity using butyrylthiocholine iodide as substrate by Ellman's colorimetric assayMore data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
Affinity DataIC50: 2.58E+3nMAssay Description:Inhibition of human BuChE measured after 15 to 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
TargetCholinesterase(Horse)
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Indian Institute of Technology (Banaras Hindu University)
Curated by ChEMBL
Affinity DataIC50: 2.89E+3nMAssay Description:Inhibition of equine BChE using BTCI as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Universidade Federal Rural do Rio de Janeiro
Curated by ChEMBL
Affinity DataIC50: 3.21E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair