BDBM50008954 3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-1-methoxy-pyrrolidin-2-one::3-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(E)-ylidene]-1-methoxy-pyrrolidin-2-one::CHEMBL12594::E-5110

SMILES CON1CC\C(=C/c2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)C1=O

InChI Key InChIKey=NJTQENWDJVHUOX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50008954   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008954(CHEMBL12594 | 3-[1-(3,5-Di-tert-butyl-4-hydroxy-ph...)
Affinity DataIC50: 560nMAssay Description:Inhibition of 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calcium ionophore A-23187More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008954(CHEMBL12594 | 3-[1-(3,5-Di-tert-butyl-4-hydroxy-ph...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against cyclooxygenase in rat basophilic leukemia cells using prostaglandin G/H synthase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008954(CHEMBL12594 | 3-[1-(3,5-Di-tert-butyl-4-hydroxy-ph...)
Affinity DataIC50: 4.30E+3nMAssay Description:Tested for inhibition of 5-LO by measuring the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008954(CHEMBL12594 | 3-[1-(3,5-Di-tert-butyl-4-hydroxy-ph...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed