BDBM50403371 Firazyr::HOE-140::ICATIBANT

SMILES NC(N)=NCCC[C@@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C[C@@H]2CCCC[C@@H]21

InChI Key InChIKey=ZVODISFSQZMJPU-UHFFFAOYSA-N

Data  4 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50403371   

TargetB2 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataKi:  0.0640nMAssay Description:Binding affinity against human cloned Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Rat)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataKi:  0.0770nMAssay Description:Binding affinity against rat bradykinin B2 receptors expressed in CHO cells using [3H]bradykinin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 0.0900nMAssay Description:In vitro inhibitory activity towards bradykinin receptor B2 using [3H]BK (0.06 nM) as a radioligand in guinea pig ileum membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 0.0900nMAssay Description:Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 0.0900nMAssay Description:Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 0.0900nMAssay Description:Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 0.0900nMAssay Description:Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 0.490nMAssay Description:In vitro inhibitory activity towards human bradykinin receptor B2 expressed in CHO cells using [3H]BK (1.0 nM) as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 0.490nMAssay Description:Inhibition specific binding of [3H]BK (1.0 nM) to human Bradykinin receptor B2 which was expressed in CHO (Chinese hamster ovary) cells by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataKi:  0.790nMAssay Description:Binding affinity to B2 bradykinin receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetB2 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of B2R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetB2 bradykinin receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 1.10nMAssay Description:In vitro antagonistic activity for Bradykinin receptor B2 by guinea pig ileal membrane receptor assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403371BDBM50403371(Firazyr | HOE-140 | ICATIBANT)
Affinity DataIC50: 5.40nMAssay Description:In vitro antagonistic activity for Bradykinin receptor B2 by guinea pig pulmonary artery assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed