BDBM50422751 DENFIVONTINIB::Denfivontinib::G-749

SMILES CN1CCC(CC1)Nc1nc(Nc2ccc(Oc3ccccc3)cc2)c2c(n1)c(Br)c[nH]c2=O

InChI Key InChIKey=SXWMIXPJPNCXQQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50422751   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422751(Denfivontinib | G-749 | DENFIVONTINIB | US12350272...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FLT3 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422751(Denfivontinib | G-749 | DENFIVONTINIB | US12350272...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of FLT3-D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Oscotec

US Patent
LigandPNGBDBM50422751(Denfivontinib | G-749 | DENFIVONTINIB | US12350272...)
Affinity DataIC50: 55nMAssay Description:Compounds of Formula (I) as obtained above were initially diluted to 10 nM in 100% DMSO (CALBIOCHEM™) for storage and made into kinase buffer solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Oscotec

US Patent
LigandPNGBDBM50422751(Denfivontinib | G-749 | DENFIVONTINIB | US12350272...)
Affinity DataIC50: 55nMAssay Description:Compounds of Formula (I) as obtained above were initially diluted to 10 nM in 100% DMSO (CALBIOCHEM™) for storage and made into kinase buffer solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Oscotec

US Patent
LigandPNGBDBM50422751(Denfivontinib | G-749 | DENFIVONTINIB | US12350272...)
Affinity DataIC50: 550nMAssay Description:Compounds of Formula (I) as obtained above were initially diluted to 10 nM in 100% DMSO (CALBIOCHEM™) for storage and made into kinase buffer solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent