BDBM50454876 HCV 796::HCV-796::Nesbuvir

SMILES CNC(=O)c1c(oc2cc(N(CCO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1

InChI Key InChIKey=WTDWVLJJJOTABN-UHFFFAOYSA-N

Data  1 IC50  7 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50454876   

TargetRNA-directed RNA polymerase(Hepatitis C virus)
Presidio Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50454876(HCV 796 | HCV-796 | Nesbuvir)
Affinity DataEC50:  9nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected human HuH7 replicon cells assessed as reduction in viral RNA level after 3 days by RT-PCR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Presidio Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50454876(HCV 796 | HCV-796 | Nesbuvir)
Affinity DataEC50:  5nMAssay Description:Inhibition of HCV genotype 1a NS5A polymerase L31V/Y93H double mutant infected in human HuH7 replicon cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Presidio Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50454876(HCV 796 | HCV-796 | Nesbuvir)
Affinity DataEC50:  12nMAssay Description:Inhibition of HCV genotype 1b NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50454876(HCV 796 | HCV-796 | Nesbuvir)
Affinity DataIC50:  160nMAssay Description:Inhibition of Hepatitis C virus genotype 1b NS5B Cdelta21 RNA dependent RNA polymerase 316N mutant using biotinylated polyC:oligoG/[alpha-P33]-GTP as...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Presidio Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50454876(HCV 796 | HCV-796 | Nesbuvir)
Affinity DataEC50:  72nMAssay Description:Inhibition of HCV genotype 2a NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Presidio Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50454876(HCV 796 | HCV-796 | Nesbuvir)
Affinity DataEC50:  19nMAssay Description:Inhibition of HCV genotype 3a NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Presidio Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50454876(HCV 796 | HCV-796 | Nesbuvir)
Affinity DataEC50:  21nMAssay Description:Inhibition of HCV genotype 4a NS5B polymerase infected in human HuH7 replicon cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Presidio Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50454876(HCV 796 | HCV-796 | Nesbuvir)
Affinity DataEC50:  24nMAssay Description:Inhibition of HCV genotype 1a NS5A polymerase infected in human HuH7 replicon cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed