BDBM50240404 (Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3-yl)-2-methyl-propan-1-one::1-(2-isopropylH-pyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one::CHEMBL19449::IBUDILAST
SMILES CC(C)C(=O)c1c(nn2ccccc12)C(C)C
InChI Key InChIKey=ZJVFLBOZORBYFE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50240404
Affinity DataKi: 3.09E+4nMAssay Description:Non-competitive inhibition of recombinant human MIF assessed as inhibition constant using varying levels of p-hydroxyphenylpyruvate as substrate by L...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 166nMAssay Description:Inhibition of human PDE4D expressed in insect sf9 cells using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of human PDE5A catalytic domain using cAMP/cGMP substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrateMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Heriot-Watt University
Curated by ChEMBL
Heriot-Watt University
Curated by ChEMBL
Affinity DataIC50: 2.99E+5nMAssay Description:Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of human PDE4AMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
Affinity DataIC50: 239nMAssay Description:Inhibition of human PDE4CMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital
Curated by ChEMBL
Affinity DataIC50: 166nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
Affinity DataKd: 1.40E+3nMAssay Description:Binding affinity to recombinant biotinylated human MIF expressed in Escherichia coli BL21 DE3 by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of human PDE4A expressed in insect sf9 cells using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of human PDE4B expressed in insect sf9 cells using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 239nMAssay Description:Inhibition of human PDE4C expressed in insect sf9 cells using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 900nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assayMore data for this Ligand-Target Pair