BDBM50214857 3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methylamino)benzonitrile::CHEMBL387748::IN-1166

SMILES Cc1cccc(n1)-c1nc(CNc2cccc(c2)C#N)[nH]c1-c1ccc2nccnc2c1

InChI Key InChIKey=SVFWZNDJPVECNU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50214857   

TargetTGF-beta receptor type-1(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50214857(IN-1166 | 3-((5-(6-methylpyridin-2-yl)-4-(quinoxal...)
Affinity DataIC50: 12nMAssay Description:Antagonistic activity at TGFBR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50214857(IN-1166 | 3-((5-(6-methylpyridin-2-yl)-4-(quinoxal...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant ALK5 phosphorylation expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50214857(IN-1166 | 3-((5-(6-methylpyridin-2-yl)-4-(quinoxal...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKCmuMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50214857(IN-1166 | 3-((5-(6-methylpyridin-2-yl)-4-(quinoxal...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50214857(IN-1166 | 3-((5-(6-methylpyridin-2-yl)-4-(quinoxal...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of human recombinant p38alpha MAPK expressed in Escherichia coli by radioisotopic protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed