BDBM50075183 1,4,5-Insp3::1D-myo-inositol 1,4,5-triphosphate::1D-myo-inositol 1,4,5-tris(dihydrogen phosphate)::1D-myo-inositol 1,4,5-trisphosphate::3,5,6-trioxyphosphate-1,2,4-cyclohexanetriol::CHEMBL279107::D-myo-inositol 1,4,5-trisphosphate::IP3::InsP3
SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
InChI Key InChIKey=MMWCIQZXVOZEGG-XJTPDSDZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50075183
Affinity DataKi: 1.50E+4nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (S substrate)More data for this Ligand-Target Pair
Affinity DataEC50: 126nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
Affinity DataKd: 195nMpH: 7.4Assay Description:Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4More data for this Ligand-Target Pair
TargetInositol 1,4,5-trisphosphate receptor type 3(Bovine)
Laboratoire De Pharmacochimie De La Communication Cellulaire Umr 7081 Du Cnrs
Curated by ChEMBL
Laboratoire De Pharmacochimie De La Communication Cellulaire Umr 7081 Du Cnrs
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes.More data for this Ligand-Target Pair
Affinity DataKd: 260nMAssay Description:Dissociation constant of the compound was determined using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 24.8nMAssay Description:Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular storesMore data for this Ligand-Target Pair
Affinity DataKd: 12.5nMAssay Description:Displacement of [3H]IP3 from full-length rat recombinant IP3R1 expressed in chicken DT40 cells by equilibrium competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.32nMAssay Description:Displacement of [3H]IP3 from rat recombinant N-terminal IP3R1 (1-604) expressed in chicken DT40 cells by equilibrium competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.210nMAssay Description:Displacement of [3H]IP3 from rat recombinant IP3R1 binding core residue (224-604) expressed in chicken DT40 cells by equilibrium competitive binding ...More data for this Ligand-Target Pair
Affinity DataEC50: 24.8nMAssay Description:Activity at rat IP3 type 1 receptor expressed in DT40 cell assessed as calcium ion mobilizationMore data for this Ligand-Target Pair
TargetInositol-trisphosphate 3-kinase A(Rat)
Pohang University of Science & Technology
Curated by ChEMBL
Pohang University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 4.37E+4nMAssay Description:Binding affinity of the compound against recombinant plasmid rat brain IP3K by overexpressing in E. coliMore data for this Ligand-Target Pair
TargetInositol-trisphosphate 3-kinase A(Rat)
Pohang University of Science & Technology
Curated by ChEMBL
Pohang University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 6.30E+3nMAssay Description:Binding affinity of the compound against recombinant plasmid rat brain IP3K by overexpressing in E. coliMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Binding affinity of compound was determined by its ability to displace specifically bound Inositol 1,4,5-trisphosphate receptor from purified porcine...More data for this Ligand-Target Pair
TargetInositol-trisphosphate 3-kinase A(Rat)
Pohang University of Science & Technology
Curated by ChEMBL
Pohang University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 4.37E+4nMAssay Description:Binding affinity of the compound against recombinant plasmid rat brain IP3K by overexpressing in E. coliMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Compound was tested for inhibition of specific [3H]Ins(1,4,5)P3 binding to Inositol 1,4,5-trisphosphate receptor in rat cerebellar membranes.More data for this Ligand-Target Pair
Affinity DataEC50: 23nMAssay Description:Agonist activity at rat IP3R1 expressed in chicken DT40 cells assessed as induction of Ca2+ releaseMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:The compound was tested for inhibitory activity against Inositol 1,4,5-trisphosphate receptor in SH-SY5Y cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:The compound was tested for inhibitory activity against Inositol 1,4,5-trisphosphate receptor in L15 cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:The compound was tested for inhibitory activity against IInositol 1,4,5-trisphosphate receptor in SH-SY5Y cell lineMore data for this Ligand-Target Pair
Affinity DataEC50: 209nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 132nMAssay Description:Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 209nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
Affinity DataKd: 8.70nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 8.70nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 133nMAssay Description:Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
Affinity DataKd: 8.70nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 126nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Compound was tested for inhibition of specific [3H]Ins(1,4,5)P3 binding to Inositol 1,4,5-trisphosphate receptor in rat cerebellar membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Binding affinity against Ins(1,4,5)P3 receptor in swiss 3T3 cellsMore data for this Ligand-Target Pair