BDBM716453 JAK344::US20250034112, Compound 12

SMILES Nc1nc(Oc2ccc(CC(=O)C[C@H](CCc3ccccc3)C(=O)O)cc2)c2cc[nH]c2n1

InChI Key InChIKey=GWQCKLGDCHSZKC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 716453   

TargetTyrosine-protein kinase JAK2 [536-812,V617F](Human)
Yale University

US Patent
LigandPNGBDBM716453(JAK344 | US20250034112, Compound 12)
Affinity DataIC50: 62nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Yale University

US Patent
LigandPNGBDBM716453(JAK344 | US20250034112, Compound 12)
Affinity DataKd:  75nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Yale University

US Patent
LigandPNGBDBM716453(JAK344 | US20250034112, Compound 12)
Affinity DataIC50: 75nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Yale University

US Patent
LigandPNGBDBM716453(JAK344 | US20250034112, Compound 12)
Affinity DataIC50: 3.36E+3nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent