BDBM50374404 CHEMBL270479::JNJ-1930942

SMILES OCc1sc(Nc2ccc(F)c(c2)C(F)(F)F)nc1-c1ccncc1

InChI Key InChIKey=JBSVHWCIKVSTTH-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50374404   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Qingdao University Medical College

Curated by ChEMBL
LigandPNGBDBM50374404(JNJ-1930942 | CHEMBL270479)
Affinity DataEC50:  1.90E+3nMAssay Description:Positive allosteric modulation of human alpha7 nAChR expressed in rat GH4-C1 cells assessed as potentiation of choline-induced Ca2+ level preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Qingdao University Medical College

Curated by ChEMBL
LigandPNGBDBM50374404(JNJ-1930942 | CHEMBL270479)
Affinity DataEC50:  1.90E+3nMAssay Description:Positive allosteric modulation of human alpha7 nAChR expressed in rat GH4-C1 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Qingdao University Medical College

Curated by ChEMBL
LigandPNGBDBM50374404(JNJ-1930942 | CHEMBL270479)
Affinity DataEC50:  4.20E+3nMAssay Description:Activity at human alpha-7 nACh receptor expressed in Xenopus laevis oocyte assessed as increase in acetylcholine-induced currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed