BDBM50210550 CHEMBL242968::MCL-448::N-cyclopropylmethylmorphinan-3-amino-urea

SMILES NC(=O)Nc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CC3)c2c1

InChI Key InChIKey=HEUGOTHWUMOSSR-FBBABVLZSA-N

Data  3 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50210550   

TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210550(CHEMBL242968 | MCL-448 | N-cyclopropylmethylmorphi...)
Affinity DataKi:  0.610nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210550(CHEMBL242968 | MCL-448 | N-cyclopropylmethylmorphi...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210550(CHEMBL242968 | MCL-448 | N-cyclopropylmethylmorphi...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210550(CHEMBL242968 | MCL-448 | N-cyclopropylmethylmorphi...)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210550(CHEMBL242968 | MCL-448 | N-cyclopropylmethylmorphi...)
Affinity DataIC50:  380nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50210550(CHEMBL242968 | MCL-448 | N-cyclopropylmethylmorphi...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed