BDBM50479470 CHEMBL489586::MK-4965

SMILES Nc1ccc2c(COc3ccc(Cl)c(Oc4cc(Cl)cc(c4)C#N)c3)n[nH]c2n1

InChI Key InChIKey=KXDIHAQCVNNLIB-UHFFFAOYSA-N

Data  2 KI  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50479470   

TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Labs.

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataKi:  0.390nMAssay Description:Inhibition of Human immunodeficiency virus reverse transcriptase K103N mutant by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Labs.

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataKi:  0.390nMAssay Description:Inhibition of Human immunodeficiency virus reverse transcriptase K103N mutant by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of HIV1 isolate R8 reverse transcriptase Y181C mutant after 90 mins by electrochemiluminescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Labs.

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of HIV1 RT polymerase K103N mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of HIV1 RT polymerase Y181C mutant by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Labs.

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of HIV1 isolate R8 reverse transcriptase K103N mutant after 90 mins by electrochemiluminescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of HIV1 isolate R8 reverse transcriptase after 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50479470(CHEMBL489586 | MK-4965)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of wild type HIV1 RT polymerase by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed