BDBM50344263 (+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(+)-MK-801::(+)MK-801::(+/-) MK-8011-methyl-(9R,1R)-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(+/-)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(+/-)-MK801::(-)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(-)-MK801::(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^{2,7}.0^{10,15}]hexadeca-2(7),3,5,10(15),11,13-hexaene::(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^{2,7}.0^{10,15}]hexadeca-2,4,6,10(15),11,13-hexaene::(5S,10R)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]cyclohepten-5,10-imine::(5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]cyclohepten-5,10-imine::(Dizocilpine)1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(MK-801)1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene(MK-801)::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10,12,14-hexaene::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10(15),11,13-hexaene::10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine.(MK-801)::CHEMBL284237::MK-801::MK-801 (Dizocilpine)::dizocilpine

SMILES C[C@@]12c3ccccc3C[C@@H](N1)c4c2cccc4

InChI Key InChIKey=LBOJYSIDWZQNJS-UHFFFAOYSA-N

Data  3 KI  9 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50344263   

TargetLysosomal Pro-X carboxypeptidase(Mouse)
University of Urbino

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetLysosomal Pro-X carboxypeptidase(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of [3H]-TCP binding to PCP receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetLysosomal Pro-X carboxypeptidase(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of [3H]1-[1-(2-thienyl) piperidine ([3H]TCP) binding to phencyclidine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataKi:  9nMAssay Description:Ability to displace [3H]TCP from high affinity PCP N-methyl-D-aspartate glutamate receptor in rat brain homogenates in vitro was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at NR2A transfected in oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataKi:  31nMAssay Description:Ability to displace [3H]TCP from high affinity PCP N-methyl-D-aspartate glutamate receptor in rat brain homogenates in vitro was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataKi:  31nMAssay Description:Ability to displace [3H]TCP from high affinity PCP N-methyl-D-aspartate glutamate receptor in rat brain homogenates in vitro was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of [3H]NANM binding to sigma receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of [3H]- N-allylnormetazocine ([3H]NANM) binding to sigma receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of specific binding of [125I]PIPAG to sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of specific binding of [3H]NANM of sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Normandie Univ

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344263BDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based El...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed