BDBM50060917 ON-01910::Rigosertib

SMILES COc1ccc(cc1NCC(=O)O)CS(=O)(=O)/C=C/c2c(cc(cc2OC)OC)OC

InChI Key InChIKey=OWBFCJROIKNMGD-UHFFFAOYSA-N

Data  1 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50060917   

TargetSerine/threonine-protein kinase PLK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant Plk1 (unknown origin) preincubated for 30 mins before recombinant Cdc25C substrate addition by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 15nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed