BDBM50095522 2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-N-[1-(5-tert-butyl-[1,3,4]oxadiazole-2-carbonyl)-2-methyl-propyl]-acetamide::2-(5-amino-6-oxo-2-phenylpyrimidin-1(6H)-yl)-N-(1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl)acetamide::CHEMBL25892::ONO-6818

SMILES CC(C)C(NC(=O)Cn1c(ncc(N)c1=O)-c1ccccc1)C(=O)c1nnc(o1)C(C)(C)C

InChI Key InChIKey=YSIHYROEMJSOAS-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50095522   

TargetNeutrophil elastase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50095522(ONO-6818 | 2-(5-amino-6-oxo-2-phenylpyrimidin-1(6H...)
Affinity DataKi:  12nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50095522(ONO-6818 | 2-(5-amino-6-oxo-2-phenylpyrimidin-1(6H...)
Affinity DataKi:  12nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50095522(ONO-6818 | 2-(5-amino-6-oxo-2-phenylpyrimidin-1(6H...)
Affinity DataKi:  12.2nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50095522(ONO-6818 | 2-(5-amino-6-oxo-2-phenylpyrimidin-1(6H...)
Affinity DataKi:  12.2nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed