BDBM50511109 Cilofexor::GS 9674::Gs-9674::PX-104::PX104::US12215098, Compound PX-104

SMILES O=C(O)c1ccnc(N2CC(O)(c3ccc(OCc4c(-c5c(Cl)cccc5Cl)noc4C4CC4)cc3Cl)C2)c1

InChI Key InChIKey=KZSKGLFYQAYZCO-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50511109   

TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511109BDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104 | U...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511109BDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104 | U...)
Affinity DataEC50:  58nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBile acid receptor(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511109BDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104 | U...)
Affinity DataEC50:  65.2nMAssay Description:Purpose of the Assay:Activation of FXR binding reaction by the compound was detected by the amplified luminescent proximity homogeneous assay (alphas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2025
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511109BDBM50511109(Cilofexor | GS 9674 | Gs-9674 | PX-104 | PX104 | U...)
Affinity DataIC50: 9.47E+3nMAssay Description:Inhibition of HSD17B13 (unknown origin) using beta-estradiol and FAC-NAD+ as substrate incubated for 2 hrs by NAD(P)H-Glo detection reagent based lum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed