BDBM50645473 Pf-07817883::PF-07817883::Ibuzatrelvir

SMILES COC(=O)N[C@H](C(=O)N1C[C@H](C(F)(F)F)C[C@H]1C(=O)N[C@H](C#N)C[C@@H]1CCNC1=O)C(C)(C)C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50645473   

TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645473(Pf-07817883 | PF-07817883 | Ibuzatrelvir)
Affinity DataKi:  2.5nMAssay Description:Inhibition of SARS-Cov-2 MPro assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50645473(Pf-07817883 | PF-07817883 | Ibuzatrelvir)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of OCT1 (unknown origin) expressed in HEK293 cells using [14C]-metformin probe as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSolute carrier family 22 member 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645473(Pf-07817883 | PF-07817883 | Ibuzatrelvir)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of OAT3 (unknown origin) expressed in HEK293 cells using [3H]-estrone-3-sulfate probe as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645473(Pf-07817883 | PF-07817883 | Ibuzatrelvir)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in HEK293 cells using N-methyl quinidine as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50645473(Pf-07817883 | PF-07817883 | Ibuzatrelvir)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of BCRP (unknown origin) expressed in HEK293 cells using rosuvastatin as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMultidrug and toxin extrusion protein 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645473(Pf-07817883 | PF-07817883 | Ibuzatrelvir)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of MATE1 (unknown origin) expressed in HEK293 cells using [14C]-metformin probe as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50645473(Pf-07817883 | PF-07817883 | Ibuzatrelvir)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of OCT2 (unknown origin) expressed in HEK293 cells using [14C]-metformin probe as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed