BDBM43868 3-[2-[4-[bis(4-fluorophenyl)methylene]piperidino]ethyl]-2-thioxo-1H-quinazolin-4-one::3-[2-[4-[bis(4-fluorophenyl)methylidene]-1-piperidinyl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one::3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one::DIACYLGLYCEROL KINASE INHIBITOR II::MLS000069510::R 59949::SMR000058550::cid_657356
SMILES Fc1ccc(cc1)C(=C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1)c1ccc(F)cc1
InChI Key InChIKey=ZCNBZFRECRPCKU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 43868
Affinity DataIC50: 300nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
TargetDiacylglycerol kinase gamma(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human DGK gamma using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human DGK alpha using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetSolute carrier family 12 member 5(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Affinity DataEC50: 8.80E+3nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
TargetDiacylglycerol kinase zeta(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DGK zeta using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase iota(Homo sapiens)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DGK iota using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase beta(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DGK beta using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of OST-tagged DGKalpha (unknown origin) expressed in MDCK cell homogenates using DAG as substrate measured after 5 mins in presence of [ga...More data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of OST-tagged DGKalpha (unknown origin) expressed in MDCK cell homogenates using DAG as substrate measured after 5 mins in presence of [ga...More data for this Ligand-Target Pair
TargetMitochondrial import inner membrane translocase subunit TIM10(Baker's yeast)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 1.27E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
TargetSolute carrier family 12 member 5(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Affinity DataEC50: 1.33E+4nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of pig FLAG3-tagged DGKalpha expressed in African green monkey COS7 cells using 1,2-dioleoyl-sn-glycerol as substrate measured after 30 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of pig FLAG3-tagged DGKalpha expressed in African green monkey COS7 cells using 1,2-dioleoyl-sn-glycerol as substrate measured after 30 mi...More data for this Ligand-Target Pair
TargetSolute carrier family 12 member 5(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Affinity DataEC50: 2.55E+4nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
TargetSolute carrier family 12 member 5(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Affinity DataEC50: 1.81E+5nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair