BDBM50047098 1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1-yl]-ethyl}-4,5-dihydro-1H,3H-2-thia-1,2a-diaza-acenaphthylene 2,2-dioxide::CHEMBL274728::RP-68303

SMILES O=S1(=O)N(CCN2CCC(Cc3c[nH]c4ccc(F)cc34)CC2)c2cccc3c2N1CCC3

InChI Key InChIKey=NZUSTSFFNOEAHE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50047098   

LigandChemical structure of BindingDB Monomer ID 50047098BDBM50047098(RP-68303 | 1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-...)
Affinity DataIC50: 1.20nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSodium-dependent serotonin transporter(Rat)
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50047098BDBM50047098(RP-68303 | 1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50047098BDBM50047098(RP-68303 | 1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-...)
Affinity DataIC50: 100nMAssay Description:Binding affinity at dopamine receptor D2 by the inhibition of binding to [3H]spiperone in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed