BDBM26545 1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}piperidine-3-thiol::Racemic::thiol-arylsulfonamide, 4d
SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N1CCCC(S)C1
InChI Key InChIKey=NVJUVGMOOGFJLZ-UHFFFAOYSA-N
Data 5 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 26545
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Vertex Pharmaceuticals
Vertex Pharmaceuticals
Affinity DataKi: 55nM ΔG°: -9.80kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
Affinity DataKi: 90nM ΔG°: -9.51kcal/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 700nM ΔG°: -8.31kcal/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 800nM ΔG°: -8.23kcal/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: >3.00E+3nM ΔG°: >-7.45kcal/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair