BDBM50034839 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester::8-Chloro-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester(Ro 15-1310)::CHEMBL415290::Ro-15-1310

SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(Cl)ccc-21

InChI Key InChIKey=QORLMYYHZLDYOR-UHFFFAOYSA-N

Data  13 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50034839   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity for Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity against alpha-1-beta-3-gamma-2 GABAA/BzR receptor subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
University of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity to human recombinant GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  9.20nMAssay Description:Binding affinity against alpha-3-beta-3-gamma-2 GABAA/BzR receptor subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  9.20nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Human)
University of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  9.20nMAssay Description:Binding affinity to human recombinant GABA alpha-3-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  16nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  16nMAssay Description:Binding affinity tested against alpha-2-beta-3-gamma-2 GABAA/BzR receptor subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  16.3nMAssay Description:Binding affinity to human recombinant GABA alpha-2-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  55nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034839(Ro-15-1310 | 8-Chloro-5-methyl-6-oxo-5,6-dihydro-4...)
Affinity DataKi:  55nMAssay Description:Binding affinity against Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed