BDBM50639239 Rolipram::(r,s)-rolipram::NSC-760125::SB-95952::ZK 62 711::ZK-62711::ZK-62771

SMILES COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50639239   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50639239(Rolipram | (r,s)-rolipram | NSC-760125 | SB-95952 ...)
Affinity DataIC50: 130nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50639239(Rolipram | (r,s)-rolipram | NSC-760125 | SB-95952 ...)
Affinity DataIC50: 190nMAssay Description:Inhibition of PDE4D7 (unknown origin) using FAM-cyclic-3'5'-AMP as substrate incubated for 1 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50639239(Rolipram | (r,s)-rolipram | NSC-760125 | SB-95952 ...)
Affinity DataIC50: 210nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50639239(Rolipram | (r,s)-rolipram | NSC-760125 | SB-95952 ...)
Affinity DataIC50: 240nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50639239(Rolipram | (r,s)-rolipram | NSC-760125 | SB-95952 ...)
Affinity DataIC50: 326nMAssay Description:Inhibition of PDE4D7 (unknown origin) using FAM-cyclic-3',5'-AMP as substrate incubated for 1 hrs by fluorescence polarization based IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50639239(Rolipram | (r,s)-rolipram | NSC-760125 | SB-95952 ...)
Affinity DataIC50: 326nMAssay Description:Inhibition of human N-terminal GST-tagged PDE4D7 (2 to 748 residues) expressed in baculovirus infected Sf9 insect cells using FAM-cyclic-3',5'-AMP as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50639239(Rolipram | (r,s)-rolipram | NSC-760125 | SB-95952 ...)
Affinity DataIC50: 460nMAssay Description:Inhibition of his-tagged recombinant human PDE4D catalytic domain (T86 to S413 residues) expressed in Escherichia coli BL21(DE3) using [3H]-cAMP as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50639239(Rolipram | (r,s)-rolipram | NSC-760125 | SB-95952 ...)
Affinity DataIC50: 590nMAssay Description:Inhibition of PDE4 (unknown origin) using [3H]cAMP/[3H]cGMP as substrate incubated for 15 mins by phosphodiesterase scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50639239(Rolipram | (r,s)-rolipram | NSC-760125 | SB-95952 ...)
Affinity DataIC50: 620nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed