BDBM50092109 3-{(S)-3-[1-(4-Carbamimidoyl-phenyl)-2-oxo-pyrrolidin-3-yl]-ureido}-propionic acid ethyl ester::3-{3-[1-(4-Carbamimidoyl-phenyl)-2-oxo-pyrrolidin-3-yl]-ureido}-propionic acid ethyl ester (SC-57099B (Orbofiban))::CHEMBL64706::SC-57099B

SMILES CCOC(=O)CCNC(=O)N[C@H]1CCN(C1=O)c1ccc(cc1)C(N)=N

InChI Key InChIKey=VJDOPFARMOLELX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50092109   

TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092109(SC-57099B | 3-{3-[1-(4-Carbamimidoyl-phenyl)-2-oxo...)
Affinity DataIC50: 2.38nMAssay Description:Tested for inhibition of the binding of fibrinogen to purified human GPIIb-IIIa in a 96-well format (ELISA assay)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092109(SC-57099B | 3-{3-[1-(4-Carbamimidoyl-phenyl)-2-oxo...)
Affinity DataIC50: 68nMAssay Description:Inhibition of platelet aggregation induced by 20 uM adenosine 5-diphosphate (ADP) in citreated human platelet rich plasma (h-PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092109(SC-57099B | 3-{3-[1-(4-Carbamimidoyl-phenyl)-2-oxo...)
Affinity DataIC50: 80nMAssay Description:Inhibition of human gel filtered platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092109(SC-57099B | 3-{3-[1-(4-Carbamimidoyl-phenyl)-2-oxo...)
Affinity DataIC50: 130nMAssay Description:Inhibition of collagen-induced platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092109(SC-57099B | 3-{3-[1-(4-Carbamimidoyl-phenyl)-2-oxo...)
Affinity DataIC50: 137nMAssay Description:Inhibition of human platelet (h-PRP) aggregation induced by 20 uM ADP with PPACKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092109(SC-57099B | 3-{3-[1-(4-Carbamimidoyl-phenyl)-2-oxo...)
Affinity DataIC50: 166nMAssay Description:Inhibition of citreated human (h-PRP) platelet aggregation induced by 5 uM TRAP6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092109(SC-57099B | 3-{3-[1-(4-Carbamimidoyl-phenyl)-2-oxo...)
Affinity DataIC50: 362nMAssay Description:Inhibition of human platelet (h-PRP) aggregation induced by 5 uM TRAP6 with PPACKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed