BDBM50029616 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole::5-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole::CHEMBL274990::SC-58125::SC58125
SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(F)cc1)C(F)(F)F
InChI Key InChIKey=JHBIMJKLBUMNAU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50029616
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human cyclooxygenase-1 (hCOX-1) enzyme.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibition of prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+5nMAssay Description:Tested for inhibition against Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+6nMAssay Description:In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 90nMAssay Description:Tested for inhibition against Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 90nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 100nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >2.00E+4nMAssay Description:IC50 value against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >2.00E+4nMAssay Description:IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasmaMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 310nMAssay Description:IC50 against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines.More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell lineMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 100nMAssay Description:Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory concentration against human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 200nMAssay Description:Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 66nMAssay Description:Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory concentration of the compound against recombinant human COX-1 (Cyclooxygenase-1)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: >2.00E+4nMAssay Description:IC50 against Prostaglandin G/H synthase 1 from human platelet rich plasmaMore data for this Ligand-Target Pair