BDBM50030619 1-Bromo-5-chloro-8-methyl-6,7,8,9-tetrahydro-2-oxa-8-aza-benzo[cd]azulene::CHEMBL123138::SK&F-105854::SK-105854

SMILES CN1CCc2c(Cl)ccc3oc(Br)c(C1)c23

InChI Key InChIKey=NYGANYRUZQPPGP-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50030619   

TargetAlpha-2B adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030619(SK-105854 | SK&F-105854 | 1-Bromo-5-chloro-8-methy...)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030619(SK-105854 | SK&F-105854 | 1-Bromo-5-chloro-8-methy...)
Affinity DataKi:  28nMAssay Description:Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030619(SK-105854 | SK&F-105854 | 1-Bromo-5-chloro-8-methy...)
Affinity DataKi:  54nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030619(SK-105854 | SK&F-105854 | 1-Bromo-5-chloro-8-methy...)
Affinity DataKi:  72nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030619(SK-105854 | SK&F-105854 | 1-Bromo-5-chloro-8-methy...)
Affinity DataKi:  783nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1B adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50030619(SK-105854 | SK&F-105854 | 1-Bromo-5-chloro-8-methy...)
Affinity DataKi:  3.30E+3nMAssay Description:Binding constant measured against Alpha-1A adrenergic receptor in human prostate; +:inactiveMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50030619(SK-105854 | SK&F-105854 | 1-Bromo-5-chloro-8-methy...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1A adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed